Check Intently (2)pentobarbital will lessen the level or impact of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Solid CYP3A4 inducers may perhaps minimize suvorexant efficacy; if improved suvorexant dose required, usually do not exceed 20 mg/daypentobarbital will minimize the extent or influence of